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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arachidonic Acid
Research Papers that Mention the Interaction
“As some ARBs have affinity for these CYP enzymes, metabolic inhibition of AA by ARBs is a possible cause for the increase in cardiovascular events.”
“In this study, we quantitatively investigated the inhibitory effects of ARBs on the formation of EETs and further metabolites, dihydroxyeicosatrienoic acids (DHETs), from AA via CYP2C8.”
Effects of Angiotensin II Receptor Blockers on Metabolism of Arachidonic Acid via CYP2C8.“Intravenous pretreatments with prazosin (0.5 mg/kg), an alpha1 adrenoceptor antagonist, [beta-mercapto-beta,beta-cyclopentamethylenepropionyl1, …-Tyr2-Arg8]-vasopressin (10 microg/kg), a vasopressin V1 receptor antagonist, or saralasin (250 microg/kg), an angiotensin II receptor antagonist , partially blocked the … response to arachidonic acid (150 microg; ….c.v.)”
Peripheral mechanisms involved in the pressor and bradycardic effects of centrally administered arachidonic acid.
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