Possible Interaction: Arachidonate and Meclofenamate

“The contractile responses to AA were antagonized in a competitive manner by pretreating the arteries with the cyclooxygenase inhibitors meclofenamate (10-5 M) or indomethacin (10-5 M), thus suggesting that the contractile response to AA was the result of its conversion to prostanoids by the cyclooxygenase pathway.”

“Indomethacin and meclofenamate potentiated vasodilatation induced by prostacyclin or endoperoxide, but reduced or abolished that caused by arachidonate.”