Possible Interaction: Arabinose and Galactose

“We showed that these two sugars are indeed consumed simultaneously by Aspergillus nidulans, while l-arabinose is utilised faster in the presence than in the absence of d-galactose.”

“ d-Galactose 1-epimerase is hyperinduced by l-arabinose , d-xylose and l-arabitol but not by xylitol.”

“Glucose, galactose and xylose significantly inhibit l‐arabinose transport by both transporters.”

“Most sugars are metabolized rather sequentially while co‐consumption of galactose and arabinose is observed.”

“Although catabolite repression of the arabinose genes by succinate or glucose was not detected at the level of transcription, both glucose and galactose were found to inhibit accumulation of arabinose when present in excess.”

“With reduced affinity, ABP also binds D-galactose (approximately 2-fold reduction) and D-fucose (approximately 40-fold reduction).”

“ ABP binds L-arabinose and D-galactose with high affinities (Kd's at 6 degrees C of 1.3 x 10(-7) and 1.9 x 10(-7) M, respectively), and both enthalpy and entropy contribute to the ABP-ligand association.”

“When ABP binds D-galactose , changes in the spectra occur which are different than those observed when L-arabinose is bound.”

“ d-Galactose strongly inhibits l-arabinose uptake by the high affinity system but only weakly inhibits such uptake by the low affinity system.”

“As a result of l-arabinose inhibition of the metabolism of the contaminating galactose , galactose itself serves as a gratuitous inducer, producing phenotypically epimeraseless yeast.”

“For example, the close similarity in specific inhibitory power of l-arabinose and d-galactose for various plant agglutinins (lectins) (1, 2), or the similarity of action of l-mannose and d-gulose, would hardly be predicted from the straight chain formulas.”