Possible Interaction: Aprotinin and Gelatin

“In a randomized study of sixty patients undergoing cardiac surgery, gelatin as prime in the heart-lung machine appeared to result in diminished efficacy of aprotinin on hemostasis, whereas it did not affect hemostasis in non-aprotinin patients.”

“Following preincubation of aprotinin with gelatin , the inhibitory effect on the trypsin activity was enhanced under the same condition as in the case of enhanced antigen-antibody reaction of aprotinin in gel in the presence of gelatin.”

“Immunoprecipitation of aprotinin preincubated with or without gelatin adjusted to equal activity per unit volume resulted in overlapping equivalence points.”

“In the immunochemical titration of aprotinin, gelatin treatment decreased the value of the equivalence point of aprotinin.”

“… gelatine was … inhibitor aprotinin was added to the injection vehicle, and hypercalcaemia then persisted for more than 8 h. 4 Of other protease inhibitors studied, e‐aminocaproic … to enhance the hypercalcaemic response to subcutaneous PTH and its fragments but, unlike aprotinin, it was ineffective in the presence of gelatine.”