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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Aprotinin
supplement:
Epinephrine
Research Papers that Mention the Interaction
“The total amount of epinephrine (median, range) used during transplantation, however, was significantly lower in patients who received aprotinin (high dose, 20, 0–170 &mgr;g; regular dose, 30, 0–140 &mgr;g), compared with patients who received placebo (70, 0–2,970 &mgr;g;P = 0.0017).”
Reduced Need for Vasopressors in Patients Receiving Aprotinin during Orthotopic Liver Transplantation“The severe pulmonary edema observed in rats given epinephrine , is very markedly reduced in animals pre-treated with either SBTI, Trasylol or Aspirin at doses which inhibit Kg consumption by the catecholamine.”
“ Aprotinine inhibited epinephrine (10(-4) M)-stimulated cyclic AMP accumulation to a greater degree than fluoride (10(-2) M)-stimulated activity.”
Inhibition of cyclic AMP accumulation in dog heart washed particle preparations by aprotinine.
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