Possible Interaction: Aprotinin and Chymotrypsin

“Third, the ability of aprotinin to neutralize, to varying degrees, the action of several serine proteases, such as trypsin, chymotrypsin , and particularly the urokinase-type plasminogen activator (uPA) and kallikreins is important, because these proteases have been implicated in tumor progression and development of metastasis.”

“The action of either chymotrypsin or trypsin was completely prevented by the serine protease inhibitor aprotinin , indicating that the proteolytic activity of the enzymes accounts for apoptosis induction.”

“ Aprotinin is a potent antifibrinolytic that inhibits several serine proteases, specifically plasmin, trypsin, chymotrypsin , kallikrein, and thrombin.”

“ Trasylol showed strong inhibitory effects on trypsin and chymotrypsin but also decreased thermolysin activity.”

“ Aprotinin , a serine proteinase inhibitor, inhibits multiple proteases including plasmin, trypsin, kallikrein, chymotrypsin , activated protein C, and thrombin.”

“Fetal calf serum and aprotinin showed strong inhibitory actions toward trypsin and chymotrypsin.”

“When co-injected with chymotrypsin , the protease inhibitor aprotinin abolished the stimulatory effect of chymotrypsin on sodium reabsorption (31.7 ± 3.4% versus 32.1 ± 2.1%), while aprotinin alone had no effect.”

“Aditionally, the presence of a digestive chymotrypsin only partially inhibited by BSTI may provide an alternative path for proteolysis.”

“ Camel chymotrypsin was more susceptible than its bovine equivalent to inhibition by soybean trypsin inhibitor and aprotinin.”

“Thus, the inhibitory properties of BPTI were improved by as much as 7 x 10(6)-fold towards elastase and 420-fold towards chymotrypsin.”