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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Aprotinin
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“Factor VIIa alone or in the presence of calcium , kept its activity even in the presence of high concentrations of aprotinin , inhibition appeared only in the presence of a factor VIIa-tissue factor complex.”
Aprotinin is a competitive inhibitor of the factor VIIa-tissue factor complex.“These suggest that aprotinin is an anti-platelet agent and may exert its action through inhibiting the Ca2+ flux.”
Effects of aprotinin in platelet aggregation and cytosolic free calcium in swine platelets.“The catalytic activity is not affected by Ca2+ and EDTA but inhibited by aprotinin and a high concentration (10(-6)M) of lima bean trypsin inhibitor.”
“ Calcium ion decreased Km for BAEE, and increased Ki of aprotinin.”
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