Possible Interaction: Aprotinin and Arachidonate

“ Aprotinin , a protease inhibitor given intravenously at a dose …,000 KIU/kg 15 minutes prior to arachidonate increased survival to 25%, and a dose of 100,000 KIU/kg improved the survival rate …% (p 2 concentrations was observed compared with the 12–14 fold increase observed in non-survivors.”

“Rather, aprotinin appears to act to enhance the clearance of arachidonate from the circulation or to inhibit cyclooxygenase or a closely related enzymatic step in the conversion of arachidonate to prostaglandin endoperoxides.”