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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Aprotinin
supplement:
Alpha-Ketoglutaric Acid
Research Papers that Mention the Interaction
“Furthermore, costunolide inhibited promoter activity of glutaminase 1 (GLS1), the first rate-limiting enzyme in glutaminolysis, and reduced mRNA and protein expression of GLS1 in HCT116 cells, The GLS1 inhibitor BPTES , similar to costunolide, significantly reduced intracellular levels of α-KG and ATP and inhibited proliferation in HCT116 cells.”
Activation of p53 by costunolide blocks glutaminolysis and inhibits proliferation in human colorectal cancer cells.
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