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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Aprotinin
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“The enzyme inhibitor Trasylol slowed the disappearance of both bioactive and immunoreactive ACTH.”
Dissociation of the disappearance of bioactive and radioimmunoreactive ACTH from plasma in man.“ Aprotinin decreases the measured concentration of ACTH , and this effect should be taken into account when interpreting results.”
“Plasma samples collected with aprotinin had significantly lower ACTH concentrations than did samples collected without aprotinin.”
Validation of a chemiluminescent enzyme immunometric assay for plasma adrenocorticotropic hormone in the dog.“ Trasylol , a serine proteinase inhibitor, suppressed completely growth hormone (GH) effect and partially reduced the effect of adrenocorticotropin (ACTH) and beta-lipotropin (beta-LPH) but did not change the effect of epinephrine.”
“It may be concluded that KPTI protects shorter chain corticotropin against digestion by proteolytic enzymes.”
“The effect of KPTI was found to be more marked in sustaining the action of corticotropin with shorter peptide chain than that with longer peptide chain.”
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