Possible Interaction: Apomorphine and Yohimbine

“The stereotypic effect of apomorphine (in mice sensitized by either scopolamine or clonidine) was antagonized by yohimbine and rauwolscine but not by corynanthine.”

“The total pecking counts, recorded for 18 min, elicited by a standard dose of apomorphine (1 mg/kg) were inhibited dose-dependently by yohimbine and the neuroleptics.”

“The effects of clonidine and apomorphine were reversed by yohimbine and haloperidol, respectively.”

“The effects of both apomorphine and DP-7-AT were partially inhibited by yohimbine (10 mg/kg i.p.).”

“The alpha-adrenoceptor antagonists prazosin, phenoxybenzamine, and yohimbine also reduced the apomorphine response significantly.”

“The behavioural effects of the simultaneous injection of yohimbine (500 microg/kg) plus apomorphine (50 microg/kg) and those of the combined treatment of haloperidol (125 microg), a nonspecific dopamine receptor antagonist, with an effective dose of yohimbine (2000 microg/kg) on sexually satiated rats were evaluated.”

“The combined treatment with subthreshold doses of apomorphine and yohimbine synergised to reverse the sexual inhibition characteristic of sexual exhaustion.”

“ Apomorphine (5 mg/kg)-induced activity was inhibited by haloperidol and yohimbine but not by prazosin.”

“The alpha 1-adrenergic antagonists piperoxane (0.03 mg/kg), yohimbine (0.03 mg/kg) or RX781094 (0.07 mg/kg) markedly potentiated apomorphine excitation.”

“In the presence of yohimbine (1 microM), apomorphine (10-1000 nM) dose-dependently inhibited the electrically evoked release.”

“The presynaptic inhibitory effects of apomorphine were competitively antagonized by sulpiride, which is considered a specific dopamine receptor antagonist, and by phentolamine and yohimbine which are considered alpha-adrenoceptor antagonists.”