Possible Interaction: Apomorphine and Vitamin C

“ Ascorbic acid also inhibited the supersensitization response of apomorphine on reserpinization (2 mg/kg i.p.).”

“ Ascorbic acid dose-dependently inhibited stereotypic behavior produced by apomorphine in mice.”

“ ascorbic acid potentiated the dopaminergic activity of apomorphine (0.5 mg/kg) and BHT-920 (0.25 mg/kg i.p.).”

“Pretreatment … ascorbic acid (10 mg/kg) or the … of ascorbic acid in the APO solution (1 mg/ml) inhibited the early (15 min) decrease in seizure threshold caused by 60 mg/kg APO and reversed the increase in seizure threshold 60 min after a 50 mg/kg APO challenge.”

“ Apomorphine and haloperidol consistently decreased AA level as well.”

“The strong potentiation effect of ascorbic acid was reproduced using apomorphine.”

“ Abstract Ascorbic acid , which is usually included in the incubation mixture when studying dopamine (DA) receptor binding sites, inhibits the specific binding of the agonists ADTN and apomorphine but not the antagonists haloperidol and spiroperidol.”

“ Apomorphine proved to be the most effective compound, fully antagonizing the effect of ascorbic acid at a concentration of 10 −6 M. A partial inhibition of the effect of ascorbic acid was induced by 10 −4 M serotonin, desipramine, imipramine and LSD.”

“The maximal effect of ascorbic acid on ATPase activities was completely antagonized by catecholamines, apomorphine , oxypertine, reserpine, tetrabenazine, phenothiazines (chlorpromazine and promethazine) and yohimbine at a concentration of 10 −4 M or below.”