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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Apomorphine
supplement:
Tyrosine
Research Papers that Mention the Interaction
“However, very large doses of apomorphine cause a haloperidolresistant inhibition of tyrosine , and probably also tryptophan, hydroxylation, which may be due to a direct inhibition of the aromatic amino acid hydroxylase involved.”
Agonist-antagonist interaction on dopamine receptors in brain, as reflected in the rates of tyrosine and tryptophan hydroxylation“The behavioral postsynaptic response to a DA receptor agonist apomorphine ) was higher in the offspring of tyrosine treated rats than in the control group.”
“ Apomorphine inhibits the conversion of tyrosine to catechols by striatal synaptosomes; neither lergotrile nor lisuride mimic this action of apomorphine.”
“ Apomorphine inhibits effectively the …]dopamine from [14C] tyrosine in slices of rat striatum (Table 2) even at and ~O-'M. Thus, striatal slices are more sensitive to the inhibition …]dopamine biosynthesis by apomorphine than tyrosine hydroxylase preparations obtained either from bovine adrenal glands or from the striatum of rats.”
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