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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Apomorphine
supplement:
Quercetin
Research Papers that Mention the Interaction
“ Quercetin is a potent inhibitor of apomorphine sulfation and may inhibit the sulfation of apomorphine in human brain in vivo.”
“ Quercetin was … apomorphine sulfation with an IC50 value, measured in 5 brain samples, of 16 +/- 2.3 nM. The inhibition mechanism of quercetin using apomorphine sulfation in … mixed, non-competitive with a Ki and Kies (mean +/- SD) of 16 +/- 4.1 and 87 +/- 37 nM, respectively (p = 0.008).”
Quercetin inhibits the sulfation of r(-)-apomorphine in human brain.“Mefenamic acid, salicylic acid and quercetin were potent inhibitors of apomorphine sulfation rate in the liver, and the IC 50 estimates were 16 ± 0.2 nM, 54 ± 8.6 µM and 18 ± 2.8 nM, respectively.”
“The non-steroidal anti-inflammatory drug mefenamic acid and the natural flavonoid quercetin inhibit the hepatic sulfation of apomorphine with an IC 50 in the order of nM.”
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