Possible Interaction: Apomorphine and Oxytocin

“Thus, oxytocin potentiated the hypermotility induced by a large dose of apomorphine and decreased the supersensitivity of the DA receptors.”

“ Apomorphine seems to activate a group of oxytocinergic neurones in this hypothalamic nucleus that project to extrahypothalamic brain areas, e.g. the hippocampus, the medulla oblongata and the spinal cord that control erectile function [5±8].”

“During apomorphine test plasma OT concentrations were significantly lower in group III than in groups I and II.”

“These results suggest that stimulation of D₂, but not D₃ or D₄ receptors, by pramipexole or apomorphine increases Ca²⁺ influx in cell bodies of oxytocinergic neurons.”

“This elevation of OT secretion could be blocked by the administration of GAL together with DA, APM or PLG.”

“prevented dose-dependently either apomorphine or oxytocin responses when given 15min before apomorphine or oxytocin.”

“ Apomorphine (50-400 micrograms/kg) and LY 163502 (10-100 micrograms/kg) elicited dose-dependent stimulation of OT and AVP, whereas CY 208-243 did not significantly increase secretion of either hormone.”

“Administration of the dopamine receptor agonist apomorphine causes a dose-dependent increase in plasma oxytocin concentrations and dose-specific behavioral changes in rodents.”

“ Apomorphine (50-400 micrograms/kg) and LY 163502 (10-100 micrograms/kg) elicited dose-dependent stimulations of oxytocin secretion.”

“The peripheral administration of the dopamine receptor agonist, apomorphine , has been shown to stimulate the release of oxytocin (OT) into the peripheral circulation of male rats, and the release of OT was associated with increased yawning and penile erection.”

“ Apomorphine dose dependently increased the concentration of oxytocin in the plasma and hippocampus, the minimal effective dose being 80 micrograms/kg s.c.,”