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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Apomorphine
supplement:
Melatonin
Research Papers that Mention the Interaction
“Prior melatonin administration (1 and 10 mg/kg b.wt) causes a significant reduction in apomorphine (1 mg/kg b.wt) induced rotational behaviour in both 6-hydroxydopamine and quinolinic acid lesioned rats.”
Melatonin modulates apomorphine-induced rotational behaviour“In contrast, melatonin treatment significantly reduced the motor deficit following apomorphine challenge.”
“Systemic administration of apomorphine , a dopamine receptor agonist, resulted in marked inhibition of the nocturnal increase of retinal NAT activity and melatonin content.”
“After administration of melatonin (1 mg/kg), the effect of apomorphine changed more in the afternoon (1-3 p.m.) than in the morning (6-8 a.m.) or the evening (6-8 p.m.) hours.”
“At chronic administration of melatonin (1 mg/kg), irrespective of the time of the day, there was a significant attenuation of apomorphine effect.”
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