Possible Interaction: Apomorphine and Dextroamphetamine

“This study shows that, using stereotypic cageclimbing behavior in mice, chronic administration … apomorphine, and N-n-propylnorapomorphine (two direct-acting dopamine agonists) and d-amphetamine (an indirect dopamine agonist) produced an enhanced … response to a test dose of apomorphine 4, 8 and 12 days … cessation of chronic drug injections.”

“Pretreatment with l-dihydroxyphenylalanine (50 mg/kg), dl-dihydroxyphenylalanine (200 mg/ kg), dextro-amphetamine sulfate (2 mg/kg) or apomorphine hydrochloride (1.25 mg/kg) enhanced that aggression severalfold.”

“Although both locomotor and stereotypy responses to d-amphetamine were abolished, these responses were enhanced in response to apomorphine.”

“Abstract Immediately following repeated daily injections of d-amphetamine , rats showed enhanced motor stereotypies when injected with amphetamine or apomorphine.”

“In most rats, d-amphetamine and apomorphine elicited rotation in opposite directions whereas, in some rats, the two drugs elicited rotation in the same direction.”

“In two experiments, behavior induced by apomorphine was potentiated during the initial post-injection period following a course of repeated, daily administrations of d-amphetamine or cocaine, suggesting the development of supersensitive dopaminergic post-synaptic mechanisms.”

“This contralateral circling was markedly enhanced by both apomorphine and (+)-amphetamine in a dosedependent manner (Fig. 1).”

“ Dexamphetamine and GK 13 reversed the hypothermia induced by apomorphine (16 mg/kg), as well as reserpine-induced hypothermia and reserpine-induced ptosis.”

“Intravenous self-administration of d-amphetamine (0.25 mg/kg/injection) decreased in a dose-related fashion after injections of the dopaminergic agonists apomorphine and piribedil.”

“A minimally locomotor-stimulant dose of apomorphine reduced the effect of dexamphetamine.”