Possible Interaction: Apomorphine and Caffeine

“… apomorphine (0.05 mg/kg SC) andN6-(L-… mg/kg SC) were stronger for CAF than for MAP and the combination, and those of α-methyl-p-tyrosine (200 mg/kg IP, … mg/kg SC, 4 h before) were stronger for MAP and CAF alone than for the combination.”

“ Apomorphine (… caffeine (20 mg/kg SC) produced contralateral rotation in neonatal 6-OHDA, but not in vehicle-injected rats.d-Amphetamine (0.2–2 mg/kg, …-HT) releasing agent,p-chloroamphetamine (2 mg/kg, SC) produced a short-lasting and weak ipsilateral rotation in the 6-OHDA-treated rats.”

“Different from rats receiving apomorphine priming 2 weeks after 6‐hydroxydopamine lesioning, in 12 week‐lesioned rats, caffeine also induced contralateral rotation after one priming with apomorphine (0.3 mg/kg s.c.),”

“When apomorphine priming was paired to the same environment (hemispherical bowls) where rats received caffeine , rotational behaviour was significantly higher than that obtained in rats primed in an unpaired environment (cylinders).”

“This effect of caffeine has been attributed to a 'priming' effect of apomorphine which enables the supersensitive dopamine receptors to respond to caffeine and other methylxanthines.”

“A correlation was observed between the number of rotations induced by apomorphine and those induced by caffeine.”

“A relationship between the two-peak rotational pattern induced by apomorphine and the initial-peak pattern induced by caffeine was also observed.”

“However, co-administered of 15 mg/kg caffeine with 0.01, 0.02 or 0.04 mg/kg apomorphine potentiated the discriminative stimulus properties of these low apomorphine doses.”

“Theophyllamine and caffeine were found to cause considerable enhancement of the action of DA formed from DOPAP AND DA receptor agonists such as apomorphine , piribedil, and amino acid alkaloids on supersensitive DA receptors.”