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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Apomorphine
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“Compared to a saline test, APO induced a significant increase of growth hormone (GH), adrenocorticotropin (ACTH), and cortisol (COR) release and a decrease in prolactin (PRL) secretion.”
Multihormonal responses to apomorphine in mental illness“ Apomorphine potentiated the grooming induced by low doses of ACTH.”
“Compared … adrenocorticotropin … apomorphine (p<0.015 and <0.004, respectively), (2) lower growth hormone response to clonidine (p=0.001), and (3) lower responses to TRH: … thyrotropin (TSH) level (p=0.006) and the difference between 2300 and 0800 h maximum increment in serum TSH values (p=0.0001).”
“Single, subcutaneous injection of a subemetic dose of apomorphine (0.75 mg) resulted in a pronounced increase in plasma concentrations of GH, as well as ACTH , beta-endorphin, and cortisol, without induction of any serious adverse drug effects.”
“Acute treatment with apomorphine (250 μg · kg−1) resulted in an elevation of plasma ACTH concentration, peak values being reached 15 min after the injection.”
Increase in plasma ACTH after dopaminergic stimulation in rats“Administration of apomorphine prior to immune challenge augmented the normal ACTH response to this stressor at 90 min and there was a corresponding increase in the number of Fos-positive paraventricular nucleus corticotropin-releasing factor cells, paraventricular nucleus oxytocin cells and nucleus tractus solitarius catecholamine cells.”
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