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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Apigenin
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“In addition, apigenin inhibited intracellular calcium , the MAPK pathway and SphK1/S1P signaling pathway in vitro.”
Apigenin attenuates heart injury in lipopolysaccharide-induced endotoxemic model by suppressing sphingosine kinase 1/sphingosine 1-phosphate signaling pathway.“ Apigenin … calcium (0.03-3 mM) in high potassium (60 mM) medium, with an IC50 of about 48 microM. After pretreatment it also inhibited norepinephrine (NE, …-140 microM)-dependent manner with an IC50 of 63 microM. At the plateau of NE-induced tonic contraction, addition of apigenin caused relaxation.”
“Administration of apigenin resulted in a rapid increase in intracellular calcium accompanied by an increase in reactive nitrogen species (RNS) and nitric oxide (NO) levels.”
Apigenin promotes antibacterial activity via regulation of nitric oxide and superoxide anion production
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