“The potential interaction is described between caffeine and antipyrine , two drugs with a high probability of being concomitantly administered for the evaluation of liver metabolism.”
“These results suggest that antipyrine is able to increase the elimination of caffeine , probably by means of inducing its hepatic metabolism.”
“… caffeine clearance increased on … days after antipyrine dosing, and 25% (from 1.65 to 2.06 ml/min, P < 0.01) 5 days after the administration of antipyrine, …, P = 0.09) after 2 days and 26% (from 5.3 to 3.9 h, P = 0.05) after 5 days.”