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“Our data demonstrate that glipizide, antipyrine and coumarin may interfere with the classification of acetylator status measured by caffeine metabolites.”
“The potential interaction is described between caffeine and antipyrine , two drugs with a high probability of being concomitantly administered for the evaluation of liver metabolism.”
Clinical pharmacology and therapeutics • 1975 | View Paper
“The explanation may be that the addition of phenazone and caffeine altered the metabolism of phenacetin, increasing the production of N‐hydroxy‐phenacetin, a known liver carcinogen.”