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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
drug:
Antipyrine
supplement:
Caffeine
Research Papers that Mention the Interaction
“Our data demonstrate that glipizide, antipyrine and coumarin may interfere with the classification of acetylator status measured by caffeine metabolites.”
Antipyrine, coumarin and glipizide affect n-acetylation measured by caffeine test.“The potential interaction is described between caffeine and antipyrine , two drugs with a high probability of being concomitantly administered for the evaluation of liver metabolism.”
“Both caffeine and cigarette use were positively correlated with the rate of antipyrine metabolism.”
“The explanation may be that the addition of phenazone and caffeine altered the metabolism of phenacetin, increasing the production of N‐hydroxy‐phenacetin, a known liver carcinogen.”
Carcinogenicity of analgesics: Long‐term treatment of sprague‐dawley rats with phenacetin, phenazone, caffeine and paracetamol (acetamidophen)
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