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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Antipyrine and Caffeine

supplement:

Caffeine

Research Papers that Mention the Interaction

Our data demonstrate that glipizide, antipyrine and coumarin may interfere with the classification of acetylator status measured by caffeine metabolites.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie  •  1995  |  View Paper
The potential interaction is described between caffeine and antipyrine , two drugs with a high probability of being concomitantly administered for the evaluation of liver metabolism.
These results suggest that antipyrine is able to increase the elimination of caffeine , probably by means of inducing its hepatic metabolism.
caffeine clearance increased on … days after antipyrine dosing, and 25% (from 1.65 to 2.06 ml/min, P < 0.01) 5 days after the administration of antipyrine, …, P = 0.09) after 2 days and 26% (from 5.3 to 3.9 h, P = 0.05) after 5 days.
Journal of clinical pharmacy and therapeutics  •  1997  |  View Paper
Both caffeine and cigarette use were positively correlated with the rate of antipyrine metabolism.
Clinical pharmacology and therapeutics  •  1975  |  View Paper
The explanation may be that the addition of phenazone and caffeine altered the metabolism of phenacetin, increasing the production of N-hydroxyphenacetin, a known liver carcinogen.
International journal of cancer  •  1981  |  View Paper