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“RESULTS Analysis of variance showed that, while on an ipsychotics, p atients had significantly higher N-a cetylaspartate measures in the dorsolateral prefrontal cortex (p =.002).”
“Follow up studies indicated antipsychotic drugs may act by increasing NAA levels in selected brain areas (the frontal lobe and thalamus), especially during the short-time observation.”
“However, there are conflicting reports on the changes in brain NAA levels after treatment with antipsychotic drugs , which exert their therapeutic effects in part by blocking dopamine D2 receptors.”
“Subdividing the patient group into two groups depending on medication revealed that the group of patients receiving a typical neuroleptic medication showed a lower mean NAA in comparison to the group of patients receiving atypical antipsychotic drugs.”