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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Antipsychotic Agents
supplement:
D-Serine
Research Papers that Mention the Interaction
“Studies performed with Taiwanese patients indicate that D-serine significantly improves schizophrenia symptoms when used as adjuvant to conventional neuroleptics but not to clozapine.”
D-serine efficacy as add-on pharmacotherapy to risperidone and olanzapine for treatment-refractory schizophrenia“Of these, the full agonists glycine and D-serine have both shown to induce significant, large effect size reductions in persistent negative and cognitive symptoms when added to traditional or newer atypical antipsychotics in double-blind, placebo-controlled clinical studies.”
“Further, in controlled clinical trials, GLY and D-Serine enhance the ability of conventional neuroleptics such as haloperidol to improve cognitive and negative symptoms.”
“Our results suggest that decreased d-serine availability may justify combining d-serine therapy with antipsychotics in patients with schizophrenia.”
“ d-Serine therapy combined with antipsychotics significantly improved negative (SMD=-0.319, 95% CI=-0.576 to -0.061) and positive (SMD=-0.211, 95% CI=-0.413 to -0.009) symptoms in patients with schizophrenia.”
“Furthermore, D-serine improved the positive symptoms in patients with chronic schizophrenia on stable doses of antipsychotics.”
“Glycine and D-serine may somewhat improve negative symptoms when added to regular antipsychotic medication , but the results were not fully consistent and data are too few to allow any firm conclusions.”
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