Possible Interaction: Antiparkinson Agents and Caffeine

“CONCLUSION As an adjuvant treatment, ca feine in teracts with ant iparkinsonian medications an d can alter levodopa pharmacokinetics, reduce dyskinesia, and improve gait in patients with freezing of gait.”

“Cross-sensitization between caffeine and L-dopa following repeated treatment and their positive interaction during chronic co-adminstration in hemiparkinsonian mice suggest that repeated exposure to caffeine may alter L-dopa responses in PD.”

“Emerging evidence from both in vivo and in vitro studies suggests that caffeine may reduce parkinsonian motor symptoms by antagonising the adenosine A2A receptor, which is predominately expressed in the basal ganglia.”