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Discover Supplement-Drug Interactions

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Last Updated: 5 months ago

Possible Interaction: Antiparkinson Agents and Caffeine

Research Papers that Mention the Interaction

Emerging evidence from both in vivo and in vitro studies suggests that caffeine may reduce parkinsonian motor symptoms by antagonising the adenosine A2A receptor, which is predominately expressed in the basal ganglia.
The open neurology journal  •  2016  |  View Paper
CONCLUSION As an adjuvant treatment, caffeine interacts with antiparkinsonian medications and can alter levodopa pharmacokinetics, reduce dyskinesia, and improve gait in patients with freezing of gait.
CONCLUSION As an adjuvant treatment, caffeine interacts with antiparkinsonian medications and can alter levodopa pharmacokinetics, reduce dyskinesia, and improve gait in patients with freezing of gait.
CNS & neurological disorders drug targets  •  2017  |  View Paper
Cross-sensitization between caffeine and L-dopa following repeated treatment and their positive interaction during chronic co-adminstration in hemiparkinsonian mice suggest that repeated exposure to caffeine may alter L-dopa responses in PD.
Neuroscience Letters  •  2006  |  View Paper