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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Antioxidants
drug:
Zidovudine
Research Papers that Mention the Interaction
“This was prevented (110+/-79 pmol/kg/d) by simultaneous oral treatment with AZT plus antioxidant vitamins (C and E).”
AZT treatment induces molecular and ultrastructural oxidative damage to muscle mitochondria. Prevention by antioxidant vitamins.“Furthermore, the coadministration of the antiviral drug zidovudine with antioxidants increases its therapeutic potential.”
“We hypothesized that AZT exposure would increase the frequency of genotoxic end points, and that the antioxidants Tempol and WR‐1065 would protect against AZT‐induced genotoxicity.”
“Also the oxidative muscle damage produced by zidovudine treatment can be prevented with anti-oxidants6.”
“daily for 45 days) significantly protected the liver against hepatotoxicity, oxidative stress and hyperlipidaemia induced by AZT , and this alleviating property is attributed to hepatoprotective, membrane-stabilizing, antioxidant and free radical scavenging properties of SBN.”
Silibinin mitigates zidovudine-induced hepatocellular degenerative changes, oxidative stress and hyperlipidaemia in rats“ AZT also caused an increase in plasma malondialdehyde and blood oxidized glutathione levels, which was prevented by the administration of antioxidant vitamins.”
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