Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Antioxidants and Xanthohumol

supplement:

Antioxidants

supplement:

Xanthohumol

Research Papers that Mention the Interaction

We show that xanthohumol strongly inhibited Bcr-Abl expression at both mRNA and protein levels and show that xanthohumol caused elevation of intracellular reactive oxygen species and that the antioxidant N-acetylcysteine blunted xanthohumol-induced events.
Molecular Cancer Therapeutics  •  2008  |  View Paper
XN supplementation significantly increased the antioxidant enzyme activities at both 25 and 40 days.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP  •  2021  |  View Paper
Preservation of retinal CYS and of GSSG and CYSS redox potentials may indicate that XN treatment induces an increased antioxidant response , but further experiments are needed to verify this potential mechanism.
Investigative ophthalmology & visual science  •  2018  |  View Paper
Additionally, Xn evidently decreased t-BHP-stimulated cell apoptosis, ROS generation and GSH depletion but increased various anti-oxidative enzymes expression regulated by Keap1-Nrf2/ARE activation, which may be associated with AMPK and GSK3β phosphorylation.
Redox biology  •  2017  |  View Paper
In conclusion, our findings suggested that XN enhances antioxidant capacity to improve VC by regulating the Nrf2/Keap1/HO-1 pathway.
Xanthohumol XN ), a main prenylated chalcone found in hops, has antioxidant effects to inhibit VC.
Antioxidants  •  2020  |  View Paper