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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Antioxidants
drug:
Vorinostat
Research Papers that Mention the Interaction
“ Antioxidant gene expression may confer vorinostat resistance.”
Phase 1 study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA]) in patients with advanced leukemias and myelodysplastic syndromes.“Interestingly, antioxidants blocked the reduction of tumour growth caused by Vorinostat , but they were unable to inhibit anti-tumoral activity of Vorinostat plus caspase-8 inhibition.”
“When vorinostat was combined with antioxidant agents , the apoptosis of MPN cells increased in a synergistic manner.”
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