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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Antioxidants
supplement:
Vitamin K
Research Papers that Mention the Interaction
“Immunosuppressive effects of menadione were abrogated only by thiol containing antioxidants.”
Vitamin K3 suppressed inflammatory and immune responses in a redox-dependent manner“This activation was prevented by the same antioxidants that blocked protection against cytotoxicity produced by preincubation with menadione.”
“We found that intense and long-lasting CL was formed upon the redox reaction of quinones, e.g., menadione , with antioxidants , e.g., L-ascorbic acid, in the presence of luminol.”
“Furthermore it was confirmed that ALA and PFD activate diverse antioxidants mediators, however MEN decreases this response.”
“Our results showed that menadione produces a decrease in mitochondrial function, an imbalance in antioxidant enzymes, and an increase in nitrosylated proteins with a decrease in glycolysis and glucose-6-phosphate dehydrogenase.”
Neuronal Metabolism and Neuroprotection: Neuroprotective Effect of Fingolimod on Menadione-Induced Mitochondrial Damage“ Menadione also evokes a significant (p<0.001) increase in the activity of the anti-oxidant enzyme superoxide dismutase (SOD).”
“The effects of menadione were mediated by ROS because (1) the anti-developmental effect of menadione was blocked by the antioxidants dithiothreitol and Trolox and (2) menadione caused an increase in ROS generation.”
“In vitro, the antioxidant trolox protected delta-ALA-D activity against damage induced by lead or menadione.”
“The presence of antioxidants blocked the menadione but not the butyrate mediated induction of the enzyme.”
“ Menadione toxicity was blocked by antioxidants , superoxide dismutase, catalase and iron chelators, indicating that superoxide anions (O2-), hydrogen peroxide (H2O2) and hydroxyl radicals (.OH) are all involved in menadione toxicity.”
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