Possible Interaction: Antioxidants and Vitamin D

“Mitochondrial biogenesis (peroxisome proliferator‐activated receptor gamma coactivator 1‐α and nuclear respiratory factor), antioxidant (superoxide dismutase, glutathione peroxidase, and catalase), and antiapoptotic (B‐cell lymphoma‐2) genes were upregulated in the PCOS mice that treated with vitamin D3 compared with the PCOS mice without any treatment.”

“ Vitamin D , however, counteracts the activity of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase which produces ROS, and improves antioxidant capacity by enhancing the activity of antioxidative enzymes such as superoxide dismutase.”

“ Vitamin D … total antioxidant capacity (+ 51.1 ± 129.7 vs. -20.7 ± 53.3 mmol/L, P = 0.007), and significantly decreased malondialdehyde (− 0.3 ± 0.9 … C-reactive protein levels (− 2.3 ± 3.0 vs. -0.3 ± 0.8 mg/L, P = 0.001) compared with the placebo.”

“CONCLUSIONS The results showed that vi amin D su pplementation has increased the PAB le vels in teenage girls.”

“Maintenance of adequate vitamin D status may positively impact antioxidants.”

“Pre-treatment with vitamin D decreased CXCL8 and further decreased IL-6 production in PM-stimulated cultures, an effect … pathway in the anti-inflammatory actions of vitamin D. Conclusions In a study using HBECs from 18 donors, vitamin D … antioxidant responses and modulated the immune … pathological pollution-induced inflammation.”

“Additionally, there was a significant decrease in high-sensitivity C-reactive protein (–815.3 ± 1,….5 ± 1,827.3 ng/mL, p = 0.002) and a significant increase in total antioxidant capacity (113.4 ± 137.4 vs. –53.7 ± …, p < 0.001) following the supplementation of vitamin D compared ….”

“Moreover, it has been shown that Vitamin D has antiproliferative effects in liver fibrosis and that Vitamin D supplementation provides significant protection against oxidative stress-mediated complications and strengthens antioxidant defenses [4–6].”

“After the replacement of vitamin D, TAS level significantly increased (p = 0.037), and TOS and fibrinogen levels significantly decreased (p = 0.043 and p = 0.010, respectively).”

“ Vitamin D activates receptors on neurons in regions implicated in the regulation of behavior, stimulates neurotrophin release, and protects the brain by buffering antioxidant and anti-inflammatory defenses against vascular injury and improving metabolic and cardiovascular function.”