Possible Interaction: Antioxidants and Vitamin B 12

“Conclusion Vitamin B12 , folic acid, and NAC may have a protective effect as an antioxidant on reducing occupational hearing loss.”

“For nonantioxidants, vitamin B12 use both before and during chemotherapy was significantly associated with poorer disease-free survival (adjHR, 1.83; 95% CI, 1.15 to 2.92; P < .01) and overall survival (adjHR, 2.04; 95% CI, 1.22 to 3.40; P < .01).”

“The extensively used thiol antioxidants (dithiothreitol, glutathione, and N-acetylcysteine) in combination with hydroxycobalamine ( vitamin B12 ) gain toxic activity in relation to human lymphocytic leukemia cell line HL60.”

“ Cobalamin significantly compensated deficits in the antioxidant defense mechanisms, suppressed lipid per oxidation and ameliorated renal tissue damage mediated by gentamicin.”

“The antioxidant and anti-inflammatory activities can be supposed the main factors responsible for the nephroprotective effect of cobalamin.”

“Treatment with methyl donors vitamin B12 , folic acid, choline) had no protectant effect and actually enhanced the cell loss evoked by TSE; they did have a minor, synergistic interaction with antioxidants protecting against TSE effects on growth.”

“ Vitamin B12 has been demonstrated to exert antioxidant effects via direct and indirect mechanisms.”