Possible Interaction: Antioxidants and Valproic Acid

“In addition, VPA further increased proton-induced production of intracellular reactive oxygen species and suppressed expression of nuclear factor erythroid-2-related factor 2 (NRF2), a key transcription factor regulating antioxidant response.”

“ VPA showed significant antioxidant effects decreasing seizure activity, possibly depending on the presence of cerebral structural alterations, treatment time, and age.”

“This protective effect of VA and RG was associated with the up-regulated expression of antioxidant enzyme genes: CAT, GPx1, GPx4, SOD1 and SOD2.”

“Also the review of N. Cardenas-Rodriguez and coworkers describes how the antiepileptic drugs as va proic acid, o xcarbazepine, and topiramate modulate ant ioxidant status by modifying the activity of antioxidant enzymes both in human and animals models and these effects can be also independent of their principal mechanism of action.”

“We conclude that the antioxidant status of epileptic patients is modified by valproate monotherapy.”

“In fact, treatment with sodium valproate dose dependently worsened cognitive status in DOX treated animals including their brain antioxidant status , possibly leading to neuronal damage through free radical induced toxicity.”

“Also, according to the suggested mechanistic pathways of VPA side effects, a combination of VPA with antioxidants may reduce hematological side effects.”