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Last Updated: 2 years ago

Possible Interaction: Antioxidants and Ursodeoxycholate

Research Papers that Mention the Interaction

Quercetin, melatonin, lithocholic and ursodeoxycholic acids block the effect of those drugs in experimental animals by their antioxidant , anti-apoptotic and/or anti-autophagic properties.
World journal of gastroenterology  •  2017  |  View Paper
UDCA activated Nrf2 signaling to increase GPX1 and catalase expression, and protective effects of UDCA pretreatment were blocked by siRNA knockdown of these antioxidants.
UDCA increases expression of antioxidants that prevent toxic bile acids from causing DNA damage and NF-κB activation in Barrett's metaplasia.
American journal of physiology. Gastrointestinal and liver physiology  •  2014  |  View Paper
Serum bilirubin remained unchanged and total antioxidant capacity, albumin and vitamin E decreased after 12 months' UDCA treatment.
UDCA may, therefore, require supplementation with glutathione precursors and/or antioxidant cocktails to reduce oxidant stress and thus delay disease progression to cirrhosis.
Redox report : communications in free radical research  •  2006  |  View Paper
The combination of lipophilic antioxidants with ursodeoxycholic acid or NCX-1000 enhances their protective potential and could represent an interesting therapeutic approach to explore for the treatment of NASH.
Canadian journal of physiology and pharmacology  •  2007  |  View Paper
UDCA treatment partly prevented changes in the antioxidant system.
Placenta  •  2006  |  View Paper
In conclusion, UDCA treatment enhances the antioxidant defense mediated by glutathione; in doing so, this treatment prevents cardiolipin depletion and cell injury in animals with secondary biliary cirrhosis. (
Hepatology  •  2004  |  View Paper
Pan-transcriptomic analysis of the retina showed that UDCA upregulated anti-apoptotic, anti-oxidant , and anti-inflammatory genes.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics  •  2021  |  View Paper