Balneotherapy and coenzyme Q10 in clinical and experimental medicine.

 CoQ(10-OX) and alpha-tocopherol) of women with gynecological diseases by treatment with natural mineral water (Spa Lucky balneotherapy, Slovakia).

Effect of Combination Therapy with Coenzyme Q10 on Functional and Metabolic Parameters in Patients with Type 1 Diabetes Mellitus

Ubiquinone supplementation and exercise capacity in trained young and older men

Antioxidative efficacy of parallel and combined supplementation with coenzyme Q10 and d-α-Tocopherol in mildly hypercholesterolemic subjects: a randomized placebo-controlled clinical study

No effect of antioxidant supplementation in triathletes on maximal oxygen uptake, 31P-NMRS detected muscle energy metabolism and muscle fatigue.

 (1.80+/-1 microg x ml(-1), mean +/- SD) than control (0.9+/-0.21 microg ml(-1)) or placebo phase (0.9+/-0.3 microg x ml(-1)) (P<0.01).

Effects of exogenous antioxidants on oxidative stress in pregnancy

In the case of pregnant animals that received

, we have observed an increase of oxidative stress (OS)–MDA in primiparous and CP in multiparous.

The importance of plasma membrane coenzyme Q in aging and stress responses.

 can prevent lipid peroxidation chain reaction by itself or by reducing other 

The essential functions of coenzyme Q

beta2-Integrin and lipid modifications indicate a non-antioxidant mechanism for the anti-atherogenic effect of dietary coenzyme Q10.

Thus, these results strongly suggest that the anti-atherogenic effects of

 be mediated by other mechanisms beside its 

Effect of coenzyme Q10 on mitochondrial respiratory proteins in trigeminal neuralgia

 supplement in CBZ-treated TN patients reduced pain scale and oxidative stress and increased 

 levels when compared with placebo group.

Effect of Short-term Coenzyme Q10 Supplementation and Precooling on Serum Endogenous Antioxidant Enzymes of Elite Swimmers

As an antioxidant essential for adenosine triphosphate synthesis,

 supplementation prevented adverse changes of 

 enzymes during heavy trainings and swimming recording and decreased the serum level, while precooling individually increased serum level of antioxidant enzymes by itself.

Coenzyme Q10 and Oxidative Stress: Inflammation Status in Hepatocellular Carcinoma Patients after Surgery

 (vitamin E and glutathione peroxidase activity) and negatively correlated with inflammation markers after surgery; (4) Conclusion: Hepatocarcinogenesis is associated with oxidative …, and coenzyme Q10 may be considered an antioxidant therapy for patients with HCC, particularly those with higher inflammation after surgery.

Coenzyme Q in asthma.

 enzyme activities in the liver of diabetic rats (11) and in patients with coronary artery disease (12).

Effects of coenzyme Q10 supplementation on antioxidant capacity and inflammation in hepatocellular carcinoma patients after surgery: a randomized, placebo-controlled trial

ConclusionIn conclusion, we demonstrated that a dose of 300 mg/d of

 supplementation significantly increased the 

 capacity and reduced the oxidative stress and inflammation levels in HCC patients after surgery.

ResultsThe oxidative stress (p = 0.04) and inflammatory markers (hs-CRP and IL-6, p < 0.01) levels were significantly decreased, and the

 enzymes activity was significantly increased (p < 0.01) after 12 weeks of 

Alzheimer's disease and antioxidant therapy: how long how far?

 has received considerable attention over the last years as a promising approach to delay or … progression in AD either by boosting the pool of endogenous antioxidants (e.g.vitamins, 

 or melatonin) or by the intake of dietary … phenolic compounds of flavonoid or non-flavonoid type.

Effects of coenzyme Q10 supplementation (300 mg/day) on antioxidation and anti-inflammation in coronary artery disease patients during statins therapy: a randomized, placebo-controlled trial

 supplementation at 300 mg/d significantly enhances 

 enzymes activities and lowers inflammation in patients who have CAD during statins therapy.

Mediterranean diet supplemented with coenzyme Q10 induces postprandial changes in p53 in response to oxidative DNA damage in elderly subjects

We explored whether the quality of dietary fat alters postprandial oxidative DNA damage and whether supplementation with

 capacity by modifying the activation/stabilization of p53 in elderly subjects.

Complementary therapy in diabetic patients with chronic complications: a pilot study.

 and alpha-tocopherol concentrations, decreased LDH activity and contributed to improvement in heart left ventricular function in diabetics.

 decreased plasma lipid peroxides, increased concentration of 

 and improved echocardiographic parameters.

Antioxidant strategies for Alzheimer's disease

 might be of even greater potential benefit for AD, especially if the agents worked in different cellular compartments or had complementary activity (e.g. vitamins E, C and 

Coenzyme Q10 for the Protection of Lacrimal Gland against High-Dose Radioiodine Therapy-Associated Oxidative Damage: Histopathologic and Tissue Cytokine Level Assessments in an Animal Model

 decreased all cytokine levels, increased nuclear factor kappa B levels more, and increased 

 status levels significantly (p < 0.05 for each).

Coenzyme Q10 Regulates Antioxidative Stress and Autophagy in Acute Myocardial Ischemia-Reperfusion Injury

 levels and the oxidant balance, enhances autophagy, reduces myocardial apoptosis and death, and improves cardiac function in rats with acute ischemia-reperfusion injury.

Coenzyme Q10 Supplementation Prevents Iron Overload While Improving Glycaemic Control and Antioxidant Protection in Insulin-Resistant Psammomys obesus

 supplementation significantly improved blood glucose, insulin, QUICKI, 

, iron and MDA, but influenced neither NO2− levels nor the anthropometric parameters.

Protective Effects of Coenzyme Q10 Against Hydrogen Peroxide-Induced Oxidative Stress in PC12 Cell: The Role of Nrf2 and Antioxidant Enzymes

 augments cellular antioxidant defense capacity through both intrinsic free radical-scavenging activity and activation of Nrf2 and subsequently 

 enzymes induction, thereby protecting the PC12 cells from H2O2-induced oxidative cytotoxicity.

Effects of L-carnitine and coenzyme q10 on impaired spermatogenesis caused by isoproterenol in male rats.

 significantly decreased the MDA level and increased 

Coenzyme q10 regulates osteoclast and osteoblast differentiation.

 act as inhibitors of osteoclastogenesis and we also have previously demonstrated the inhibitory effect of 

Evaluation of the Protective Effects of CoQ10 on Ovarian I/R Injury: An Experimental Study

The mean oxidant marker levels and histopathologic scores for the ovarian tissue significantly decreased after using

Coenzyme Q10 treatment ameliorates acute cisplatin nephrotoxicity in mice.

 mechanisms (reduced glutathione level and superoxide dismutase activity), suppressed lipid peroxidation, decreased the elevations of tumor necrosis factor-alpha, nitric oxide and platinum ion concentration, and attenuated the reductions of selenium and zinc ions in renal tissue resulted from cisplatin administration.

[Effects of coenzyme Q10 or combined with micronutrients on antioxidant defense system in rats].

 exerted antioxidative effects in rats, and when it was supplemented in combination with other 

, the effects were raised to some extent.

Reactions of biological antioxidants: III. Composition of biological membranes

Changes in antioxidant status of myocardium during oxidative stress under the influence of coenzyme Q10

 of the myocardium induced by long-term addition of 

 into food was accompanied by decrease in the negative inotropic effect of H2O2, whereas the levels of superoxide dismutase and glutathione peroxidase after oxidative stress were virtually unchanged.

Dual involvement of coenzyme Q10 in redox signaling and inhibition of death signaling in the rat heart mitochondria.

Therefore, we have investigated dual involvement of

 in redox signaling generation through enhanced production of reactive oxygen species and death signaling inhibition through 

The effect of pharmacological doses of different antioxidants on oxidation parameters and atherogenesis in hyperlipidaemic rabbits.

No decrease in aortic atherosclerosis was measured in ubiquinone-10- and vitamin E-supplemented rabbits, despite the fact that both antioxidants decreased plasma oxidizability and

The effect of ethanol and/or food restriction on coenzyme Q in liver in rats.

 levels in the food restricted animals would result in an increase in 

 protection and might explain the observed increases in longevity.

Coenzyme Q10 protects coronary endothelial function from ischemia reperfusion injury via an antioxidant effect.

 protects coronary vascular reactivity after I/R via an 

The role of vitamin E in cellular energy metabolism in cultured adrenocortical cells

 by preventing side reactions involving lipid peroxidation.

Coenzyme Q10 inhibits intracranial aneurysm formation and progression in a mouse model

Preventing Myocardial Injury Following Non-Cardiac Surgery: A Potential Role for Preoperative Antioxidant Therapy with Ubiquinone

In a pre-clinical swine model of ischemic heart disease, we showed that daily administration of

 of mitochondria within chronically ischemic heart tissue, potentially via a PGC1α-dependent mechanism.

The effect of Co-Q10 on allergic rhinitis and allergic asthma

 treatment increased Nrf2 expression and Nrf2 induced 

, glutathione redox and inhibited inflammation, oxidative stress injury, Th2 cytokines production and attenuated allergic inflammatory responses.

Clinical Trial of the Effects of Coenzyme Q10 Supplementation on Biomarkers of Inflammation and Oxidative Stress in Diabetic Hemodialysis Patients

 (TAC) (54.921 ± 26.437 vs. −126.781 ± 26.437, P < 0.001) and nitric oxide (NO) levels (4.121 ± 1.314 vs. −….006) and decreased C-reactive protein (CRP) (−1.302 ± 0.583 vs. 0.345 ± 0.583, 0.042) levels compared with the placebo.

A Kinetic Approach to Evaluate the Structure-Based Performance of Antioxidants During Lipid Oxidation.

 number, which were considered as the quantitative measures of thermal sensitivity of the lipid system, showed changes from -40.3% and -27.2% to 13.5% and 11.5%, respectively, in the presence of the 

Identification of Ubiquinones in Honey: A New View on Their Potential Contribution to Honey’s Antioxidant State

Since the quinone group of UQs is involved in redox reaction, we discuss the possibility that

Increased oxidative stress and coenzyme Q10 deficiency in centenarians

 significantly shifted to the oxidized form and levels of strong 

, such as ascorbic acid and unconjugated bilirubin, decreased significantly compared to 76-year-old controls, indicating an increased oxidative stress in centenarians.

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