Possible Interaction: Antioxidants and Tyrosine

“The increased tyrosine radicals can be reduced by endogenic antioxidants such as GSH.”

“Plasma total antioxidant status was significantly and independently lower and higher in Y and Post M groups, respectively.”

“Separately, in oxidations by 2,2′-azobis-2-amidinopropane hydrochloride or HOCl, the presence of Tyrosine ( Tyr) or Cysteine (Cys) residue markedly enhanced antioxidant action of His-containing peptides.”

“The antioxidants ascorbate and probucol, but not vitamin E, inhibited LDL oxidation by myeloperoxidase, H2O2, and L-tyrosine.”

“Further studies to characterize the mechanism of stimulation of tyrosinolation in PMN have revealed that … inhibited the respiratory burst in stimulated PMN, e.g., an anaerobic atmosphere, or addition of antioxidants such as cysteamine, azide, or 2,3-dihydroxybenzoic …, also inhibited the peptide-induced stimulation of tyrosinolation in … cells.”

“These results indicate that acute administration of L-tyrosine may impair antioxidant defenses and stimulate oxidative damage to lipids and proteins in cerebral cortex of young rats in vivo.”

“ Antioxidants , such as superoxide dismutase (SOD), N-acetylcysteine (NAC), and pyrrolidine dithiocarbamate (PDTC), blocked tyrosine phosphorylation of I kappa B-alpha induced by silica, suggesting reactive oxygen species (ROS) may be important regulatory molecules in NF-kappa B activation through tyrosine phosphorylation of I kappa B-alpha.”

“ Antioxidant capacity was improved by feeding with tyrosine --an increase of 16.7% and 17.1% in both untreated and treated sprouts, respectively.”

“Mutation of Tyr85 in INrf2 stymied the nuclear export of INrf2, suggesting that tyrosine phosphorylation controls the pre-induction nuclear export and degradation in response to antioxidants.”