Possible Interaction: Antioxidants and Tretinoin

“The effects of ROS, retinoids , or docosahexaenoic acid were counteracted by antioxidants , with alpha-tocopherol (vitamin E) providing the best protection against ROS.”

“The antioxidant , N‐acetylcysteine, inhibited ATRA‐ND induced apoptosis.”

“In the therapy of photo-aging the local retinoids lived up to expectations, but the clinical effectiveness of antioxidant vitamins is lower than expected.”

“… antioxidants and their derivatives in combination with standard therapy may be harmful, … dietary antioxidants and their derivatives, such as vitamin A, including retinoic acid ; vitamin C; vitamin E as d-tocopheryl succinate ( -TS); and natural -carotene at … of individual dietary antioxidants may stimulate the proliferation of residual cancer cells.”

“In this study we show that addition of antioxidants to HL-60 cells cultured in the presence of 3 microM HPR, markedly suppresses the apoptopic effect of the retinoid and significantly prolongs cell survival (48-96 h).”

“Inhibitory effects such as those described here and antioxidant properties might in part contribute to the antiinflammatory and anticarcinogenic activity of retinoids in vivo.”

“In conclusion, RA treatment could increase the activity of the antioxidant enzyme, suppress the oxidative stress, inflammation response and activation of NF-κB signaling, thereby improving blood glucose level and cardiac injury of GDM mice before and after delivery.”

“However, antioxidant treatment did not ameliorate the reduction of lipid accumulation induced by ATRA , indicating that ROS generation was not involved in ATRA-inhibited adipocyte differentiation.”

“ROS are obligatory for differentiation and while H2O2 alone induces PrE, antioxidants attenuate the response to RA.”

“While some authors suggest that retinoids are potential anti-proliferative and antioxidant agents , evidence has suggested those present pro-oxidant properties, which might lead to malignant proliferation.”