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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Antioxidants
Research Papers that Mention the Interaction
“Induction of the JE gene by TNF alpha or serum was not completely inhibited by these antioxidants inhibited an increase in intracellular oxidized state of cells treated with TPA.”
“The CAT activity induced by TPA increased in parallel with the endogenous JE and mRNA level, and the increase was inhibited by the antioxidants.”
Involvement of reactive oxygen species in the induction of chemokine JE/MCP-1 gene by phorbol-12-myristate-13-acetate in Balb 3T3 cells.“The role of reactive oxygen species in the promoting action was investigated: mannitol, a scavenger of hydroxyl radicals, or antioxidants , i.e. ascorbic acid plus alpha-tocopherol, abolished the in vitro promoting effects of TPA and TCDD.”
“From these results, it is suggested that the increasing effects of six antioxidants on degranulation in the presence of TPA or antigen were dependent on [Ca2+]i increase caused by the compounds, probably through their ability to inhibit endoplasmic reticulum Ca2+-ATPase.”
“These results, therefore, suggest that GSH level-raising agents and other antioxidants might inhibit by diverse means the effects of TPA on GSH metabolism and skin tumor promotion.”
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