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Discover Supplement-Drug Interactions

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Last Updated: 4 years ago

Possible Interaction: Antioxidants and Thioredoxin-1 Inhibitor Px-12

Research Papers that Mention the Interaction

Further analysis revealed that PX-12 at low concentrations induced a JNK-dependent elevation in the Cx43 protein, which was also preventable by supplementing the cells with anti-oxidants.
Inhibition of JNK or supplement of cells with anti-oxidants prevented the cell-killing action of PX-12.
Tumor Biology  •  2015  |  View Paper
ResultsWe found that PX-12 increased nuclear Nrf2 activity and antioxidant response element binding.
Cancer Chemotherapy and Pharmacology  •  2010  |  View Paper