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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Antioxidants
drug:
Tetrahydrobiopterin
Research Papers that Mention the Interaction
“Vitamin C, folate, and other antioxidants enhance endothelial BH4 bioavailability through chemical stabilization or scavenging of reactive oxygen species, thereby contributing to the maintenance of physiological homeostasis in the endothelium.”
Regulation of tetrahydrobiopterin synthesis and bioavailability in endothelial cells“We have previously shown that tetrahydrobiopterin (BH4), an obligatory co‐factor for tyrosine hydroxylase (TH), exerts selective toxicity on dopamine‐producing cells and that this is prevented by antioxidants.”
“Furthermore, it appears that beneficial effects of some antioxidants (e.g., vitamin C) on vascular function could be mediated via increased intracellular concentration of tetrahydrobiopterin.”
“An NADPH oxidase inhibitor, apocynin, or antioxidant , N-acetyl-L-cysteine, substantially attenuated the reduction in both BH4 and NO.”
“This observation led to the hypothesis that antioxidant functions of BH4 or recoupling of inducible or neuronal NOS in other cells largely mediate the effects of BH4.”
Stay in Shape With BH4: Loss of Endothelial Tetrahydrobiopterin Promotes Aortic Aneurysm Development in Mice.
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