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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Antioxidants
drug:
Tamoxifen
Research Papers that Mention the Interaction
“Furthermore, TAM increased the level of the antioxidant ascorbate, catalase, SOD2, and methionine, as well as phase II metabolizing enzymes GSTM1 and UGT1A1 in CCl4-treated livers.”
Confounding influence of tamoxifen in mouse models of Cre recombinase-induced gene activity or modulation“Various antioxidants (vitamin E, vitamin C, β-carotene, catalase, and superoxide dismutase) inhibited all these cellular effects of Tam.”
“This antioxidant action is likely to contribute to the observed cardioprotective action of tamoxifen and supports the use of this compound in treating and even preventing breast cancer.”
“Therefore, tamoxifen might improve the antioxidant response , which is compromised in some diseases.”
“We therefore suggest that antioxidant ability may be an advantage of breast cancer treatment and prophylaxis with tamoxifen.”
“However, the mechanism by which TAM mediates antioxidant enzyme induction remains unclear.”
“ Tamoxifen (TAM), a nonsteroidal anti-estrogen that is widely used in chemotherapy, is known to be a modulator of antioxidant status.”
“It is possible that the antioxidant property of tamoxifen might contribute to its biological actions.”
The antioxidant action of tamoxifen and its metabolites Inhibition of lipid peroxidation“Results suggest that the mechanism of action of Tamoxifen administration is to modulate anti-oxidant , anti-inflammatory and anti-gliotic responses.”
Tamoxifen: an FDA approved drug with neuroprotective effects for spinal cord injury recovery
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