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Last Updated: 2 months ago

Possible Interaction: Antioxidants and Tamoxifen



Research Papers that Mention the Interaction

Furthermore, TAM increased the level of the antioxidant ascorbate, catalase, SOD2, and methionine, as well as phase II metabolizing enzymes GSTM1 and UGT1A1 in CCl4-treated livers.
Archives of Toxicology  •  2018  |  View Paper
Various antioxidants (vitamin E, vitamin C, β-carotene, catalase, and superoxide dismutase) inhibited all these cellular effects of Tam.
The Journal of Biological Chemistry  •  1996  |  View Paper
This antioxidant action is likely to contribute to the observed cardioprotective action of tamoxifen and supports the use of this compound in treating and even preventing breast cancer.
Trends in pharmacological sciences  •  1994  |  View Paper
Therefore, tamoxifen might improve the antioxidant response , which is compromised in some diseases.
Proteins  •  2015  |  View Paper
We therefore suggest that antioxidant ability may be an advantage of breast cancer treatment and prophylaxis with tamoxifen.
Breast Cancer Research and Treatment  •  2004  |  View Paper
However, the mechanism by which TAM mediates antioxidant enzyme induction remains unclear.
Tamoxifen (TAM), a nonsteroidal anti-estrogen that is widely used in chemotherapy, is known to be a modulator of antioxidant status.
Oncogene  •  2002  |  View Paper
It is possible that the antioxidant property of tamoxifen might contribute to its biological actions.
FEBS letters  •  1990  |  View Paper
Results suggest that the mechanism of action of Tamoxifen administration is to modulate anti-oxidant , anti-inflammatory and anti-gliotic responses.
Neural regeneration research  •  2016  |  View Paper