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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Antioxidants
drug:
Tadalafil
Research Papers that Mention the Interaction
“In conclusion; down-regulation of inflammatory and fibrogenic cytokines expression, restoration of oxidants/antioxidant hemostasis, antioxidant boost and promotion of angiogenesis are implicated in the observed protective effect of tadalafil.”
Tadalafil reduces airway hyperactivity and protects against lung and respiratory airways dysfunction in a rat model of silicosis.“ConclusionsA prolonged exposure to tadalafil decreases antioxidant capacity at resting condition, therefore making subjects more susceptible to the oxidative stress induced by an exhaustive bout of exercise.”
“ Tadalafil decreased malondialdehyde levels in the I/R group and increased the total antioxidant capacity level.”
The protective effects of tadalafil on renal damage following ischemia reperfusion injury in rats“ Tadalafil (TAD) prevents the accumulation of ROS and increases antioxidant cellular protective mechanisms.”
“ Tadalafil also enhanced antioxidant enzyme glutathione S-transferase Kappa-1 (GSKT-1) and downregulated redox regulatory chaperones like heat shock protein 8 (HSPA8), and 75 kD glucose regulatory protein (75GRP).”
“Cardiac oxidative stress was attenuated and antioxidant capacity was enhanced by tadalafil possibly via up-regulation of mitochondrial superoxide dismutase (MnSOD).”
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