Possible Interaction: Antioxidants and Steroids

“Post-treatment, the steroid plus antioxidant group had significantly lower tissue malondialdehyde levels and a greater fall in tissue and serum malondialdehyde, compared with the steroid group.”

“ Antioxidants and plant products are reported to reduce the genotoxic damage of steroids.”

“Intriguingly, when steroids were given in conjunction with antioxidants , not only was neonatal survival improved, but impaired cardiac function in adult life was markedly attenuated.”

“The authors also make the striking observation that this impairment can be ameliorated when steroids are given in conjunction with anti-oxidants.”

“While anti-oxidants given in conjunction with steroids ameliorated the adverse effects of steroids, when given by themselves they too had a detrimental effect on cardiac function in adult life.”

“Their induction by ovarian steroids indicates a complex upregulation of multiple components in the glutamate cycle and antioxidation , in addition to spine proliferation.”

“Reports indicate that antioxidant enzymes like the glutathione peroxidases (GPx) can be regulated by sex steroids.”

“… steroids … antioxidant properties, and ascorbic acid possesses antioxidant activity, ascorbic acid (20, 40 or 60 mg/kg of body weight) administered together with megestrol acetate (32.…) significantly decreased CAs and SCEs, suggesting an antigenotoxic role of ascorbic acid against megestrol acetate induced genotoxic damage in mice bone marrow cells.”

“ Steroids with antioxidant properties (progesterone, dehydroepiandrosterone and its sulfate ester, and 17β‐estradiol) differently prevented PS‐induced delayed cell death.”

“ Steroids combined with antioxidants may be a potential strategy for the treatment of SSNHL.”

“This steroid stimulated the activities of enzymes linked to the antioxidant system and resulted in minor damage to the chloroplast membranes.”