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Last Updated: 3 years ago

Possible Interaction: Antioxidants and Sorafenib

supplement:

Antioxidants

Research Papers that Mention the Interaction

Antioxidant NAC could alleviate the synergetic effects of DCA and sorafenib on ROS generation, JNK activation, Mcl-1 degradation, and cell apoptosis.
Experimental cell research  •  2021  |  View Paper
In vivo rats treated with sorafenib exhibited a reduction of antioxidant defence and abnormal histological alterations including hypertrophy, increased fibrosis, disordered myofibrils and damaged mitochondria, which were protected by MPG.
Basic & clinical pharmacology & toxicology  •  2019  |  View Paper
In conclusion, the anti-tumor activity of specific MKIs, such as regorafenib and sorafenib , is altered by the cellular redox status, suggesting that uncontrolled antioxidant intake during HCC treatment should be avoided or only endorsed to diminish chemotherapy-induced side effects, always under medical scrutiny.
Antioxidants  •  2021  |  View Paper