Possible Interaction: Antioxidants and Simvastatin

“Combining S-N with antioxidants reduced desmosterol and lathosterol by 37% and 31%, and elevated campesterol and β-sitosterol levels by 54% and 46%, but differences did not attain significance.”

“Conclusions—The data indicate that simvastatin can modulate expression in vitro of the antioxidant enzyme paraoxonase and is associated with increased serum paraoxonase concentration and activity.”

“The protective increase in HDL2 with simvastatin plus niacin was attenuated by concurrent therapy with antioxidants.”

“They have shown that simvastatin enhances antioxidant status (GSH-Px) in atherosclerotic aorta and decreases oxidative stress (malondialdehyde).”

“Their findings support that simvastatin combined with an antioxidant could provide neuroprotection and it may be attributed to a dampening of cerebral vascular endothelial inflammatory response.”

“The results demonstrated that simvastatin combined with an antioxidant could provide neuroprotection and it may be attributed to a dampening of cerebral vascular endothelial inflammatory response.”

“This study shows that simvastatin induces the activation and nuclear translocation of Nrf2 and the expression of various anti-oxidant enzymes via ERK and PI3K/Akt pathway in colon cancer cells.”

“Interestingly, simvastatin treatment of P3NS1 cells increased the intracellular ROS production and decreased antioxidant enzyme activity with increased P53, Bax and Caspase3 gene expression while that of Bcl2 was decreased.”

“We conclude that serum PAB values are decreased by simvastatin therapy.”

“These data indicate that simvastatin not only decreases blood lipids and circulating oxidized LDL but also increases lipid corrected levels of antioxidant vitamins and may improve plasma antioxidant status synergizing with the biological effects of antioxidants.”