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“These data indirectly suggest that antioxidant , antiperoxidative effects might be important factors in the mechanism of hepatoprotective action of silymarin.”
International journal of pharmaceutics • 2019 | View Paper
“ SIL treatment significantly reduced the levels of LDH, nitric oxide, reactive oxygen species and the oxidants/antioxidants balance in Neuro-2A cells as compared to Mn-exposed cells.”
“Silymarin SIL ) has antioxidant properties and stabilizes intracellular antioxidant defense systems.”
“For example, silymarin strongly prevents both photocarcinogenesis and skin tumor promotion in mice, in part, by scavenging free radicals and reactive oxygen species and strengthening the antioxidant system.”
“These results indirectly indicate that the scavenger silymarin is able to increase the antioxidant protection of the cells by ameliorating the deleterious effects of free radical reactions.”
“ Silymarin further strengthtened the antioxidant defense by the elevation of sulfhydryl groups concentration and reducing power property resulted in decreased total scavenger capacity.”
International immunopharmacology • 2018 | View Paper
“The pretreatment with silymarin could remarkably reduce the cytotoxicity, promote the expression of Trx and antioxidant enzymes, and suppress the TXNIP and NLRP3 inflammasome activation.”