supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 5 years ago
supplement:
Antioxidants
supplement:
Silymarin
Research Papers that Mention the Interaction
“These data indirectly suggest that antioxidant , antiperoxidative effects might be important factors in the mechanism of hepatoprotective action of silymarin.”
[Effect of silimarin (Legalon) therapy on the antioxidant defense mechanism and lipid peroxidation in alcoholic liver disease (double blind protocol)].“Therefore, formulation of silymarin may hold a great promise in the field of antioxidant agent development.”
“ SIL treatment significantly reduced the levels of LDH, nitric oxide, reactive oxygen species and the oxidants/antioxidants balance in Neuro-2A cells as compared to Mn-exposed cells.”
“Silymarin SIL ) has antioxidant properties and stabilizes intracellular antioxidant defense systems.”
“For example, silymarin strongly prevents both photocarcinogenesis and skin tumor promotion in mice, in part, by scavenging free radicals and reactive oxygen species and strengthening the antioxidant system.”
“After an 18 h treatment of cells with 36 µg/mL silymarin , total antioxidant capacity of cells significantly increased (p < 0.05).”
“These results indirectly indicate that the scavenger silymarin is able to increase the antioxidant protection of the cells by ameliorating the deleterious effects of free radical reactions.”
“ Silymarin further strengthtened the antioxidant defense by the elevation of sulfhydryl groups concentration and reducing power property resulted in decreased total scavenger capacity.”
Impact of milk thistle (Silybum marianum) on the mycotoxin caused redox-homeostasis imbalance of ducks liver.“Those receiving silymarin had significantly higher serum TAC compared to control after 21 days of therapy (p < 0.001).”
“Lisinopril and silymarin increased anti‐oxidant capacity of liver tissue.”
“The pretreatment with silymarin could remarkably reduce the cytotoxicity, promote the expression of Trx and antioxidant enzymes, and suppress the TXNIP and NLRP3 inflammasome activation.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback