“Conclusion We propose that SAMC triggers AHR/NRF2-mediated antioxidant responses which may further suppress the NLRP3/6 inflammasome pathway and NF-κB activation, contributing to the improvement of NASH.”
“The nuclear translocation of the upstream regulator of xenobiotics metabolism, AHR, and regulator of antioxidant responses , NRF2, were significantly increased by SAMC treatment.”