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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Antioxidants
supplement:
S-Adenosylmethionine
Research Papers that Mention the Interaction
“Conclusions: In summary, SAMe boosted antioxidant levels, improved diabetic measures, and hippocampal inflammatory and behavioral outcomes in aged mice.”
Obesity Prevents S-Adenosylmethionine-Mediated Improvements in Age-Related Peripheral and Hippocampal Outcomes“ SAM administration could increase the endogenous antioxidant glutathione and potentiate the antioxidant enzymes activities.”
“Our results demonstrate significant biological variability in SAM and SAH levels at baseline and during treatment with an anti-oxidant and suggest a potential mechanism for the lack of efficacy observed in trials of anti-oxidant therapy.”
“ AdoMet provoked significant lipid and protein oxidation, decreased glutathione concentrations, and altered the activity of important antioxidant enzymes in cerebral cortex and striatum.”
Disruption of Brain Redox Homeostasis, Microglia Activation and Neuronal Damage Induced by Intracerebroventricular Administration of S-Adenosylmethionine to Developing Rats“However, SAM upregulates the antioxidant enzymes mRNA transcripts and effectively diminishing DNA oxidation.”
“ AdoMet also reduced the antioxidant defenses (reduced glutathione, GSH) and Na+, K+-ATPase activity.”
“ Antioxidants such as trolox or N-acetyl cysteine prevented this synergistic toxicity of SAMe plus AA or SAMe plus BSO, respectively.”
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