Possible Interaction: Antioxidants and Rutin

“ Rutin better prevented the decrease in the antioxidant defenses , increasing SOD by 34%, CAT by 246% and GST by 84% in the liver, as well as SOD by 119% and GST by 190% in the kidney.”

“ Rutin reduced UV-induced proinflammatory response and ROS generation and enhanced the activity/levels of antioxidants (SOD, GSH-Px, vitamin E, GSH, and Trx).”

“Pretreatment with antioxidant rutin decreased ROS increment which was consistent with improved viability of olmesartan-treated cells.”

“… rutin significantly inhibited protein expressions of cytochrome P450-dependent CYP3A4 (75.3 %, p < 0.0001), … CYP1A1 enzymes (1.7-fold, p = 0.0084) and increased protein expressions of antioxidant and phase II reaction catalyzing enzymes, NQO1 (2.42-fold, … < 0.0001) and GSTP1 (2.03-fold, p < 0.0001).”

“Furthermore, quercetin or rutin treatment displayed an overall increase of the four antioxidant enzymes.”

“In conclusion, these findings demonstrated that the addition of rutin into sunscreens can markedly improve the antioxidant properties of the formulation as well as photostabilize some of the UVA filters.”

“Our research indicated that rutin protected the intracellular GSH antioxidant system and prevented H(2)O(2)-induced apoptosis of HUVECs through regulating reactive oxygen species mediated mitochondrial dysfunction pathway.”

“Mechanistically, the addition of Rutin at the concentration of 0.6, 0.8, and 1.0 mM significantly attenuated ROS accumulation and MDA production by improving antioxidant enzymatic activity, including SOD, CAT, and GSH-Px (p < .05).”

“These effects were inhibited by the antioxidant rutin.”

“ Antioxidant activities showed significant association with phenolic compounds, such as caffeoylquinic acids, ferulic acid-O-hexosides and rutin.”