Possible Interaction: Antioxidants and Resveratrol

“ RSV crosses blood brain barrier and exerts its antioxidant effect by enhancing the anti-oxidant enzymes.”

“Treatment of the cells with resveratrol or 5-aza, a demethylating agent, could prevent HG-induced reactive oxygen species production and expression of Nrf2-controlled antioxidant genes.”

“In addition, RSV upregulated Akt phosphorylation, Nrf2 phosphorylation, and expression levels of antioxidant genes HO-1, SOD-1, and CAT in a dose-dependent manner (P < 0.05) under oxidative stress.”

“The findings indicate that RES protects spermatological parameters and DNA damage, decreases GLF‐induced lipid peroxidation, improves the antioxidant defence mechanism and regenerates tissue damage in the testis of rats.”

“Treatment with CA and Res increased the levels of antioxidant and autophagy protein expression with consequently corrected levels of reactive oxygen species, mitochondrial membrane potential, mutant ataxin‐3, and the aggregation of mutant ataxin‐3 in SK‐N‐SH‐MJD78 cells.”

“Resveratrol prevents superoxide production from uncoupled endothelial nitric oxide synthase by up‐regulating the tetrahydrobiopterin‐synthesizing enzyme GTP cyclohydrolase I. In addition, resveratrol increases the expression of various antioxidant enzymes.”

“Pretreatment of cells with RSVL , curcumin, and EEAC increased the cell antioxidant ability by improving the activity of superoxide dismutase (SOD), prevented or limited intracellular damage, and ameliorated the harmful effects of ROS.”

“During preconditioning, small doses of resveratrol can exert an adaptive stress response, forcing the expression of cardioprotective genes and proteins such as heat shock and antioxidant proteins.”

“ Resveratrol directly upregulates antioxidative capacity by increasing antioxidant genes such as heme oxygenase-1, superoxide dismutase, catalase, and glutathione.”

“ Antioxidant activities of resveratrol loaded NFs were significantly higher than that of free resveratrol.”