Possible Interaction: Antioxidants and Pulmonary Surfactants

“These findings suggest that antioxidants , particularly in combination, prevent LPO of lung surfactant.”

“With supplements of antioxidants (except vitamin C), superoxide radical production and the surfactant LPO level fell in a dose-dependent manner.”

“CLINICAL SIGNIFICANCE The addition of a su factant to the ant ioxidant formulation si gnificantly reduced microleakage when it was applied after bleaching.”

“In this study, surfactin caused reactive oxygen species (ROS) generation and the surfactin-induced cell death was prevented by antioxidants N-acetylcysteine (NAC) and catalase, suggesting involvement of ROS generation in surfactin-induced cell death.”

“In the context of the known oxidant burden present in the lower respiratory tract of …, these observations of a "GSH deficiency" in IPF ELF suggest that there is a marked oxidant-antioxidant … alveolar surface of these persons, thus increasing the susceptibility to … epithelial cell damage characteristic of this disease.”

“All in all, enteral surfactant administration increased antioxidant enzyme activity and decreased lipid peroxidation, and tipped the balance between the production of reactive oxygen species and the gut’s ability to detoxify them in favor of reduced oxidative stress.”

“Moreover, a nonlinear dependency of surfactant effectiveness is observed with the increase in chain length of the lipophilic antioxidants.”