Possible Interaction: Antioxidants and Propofol

“Despite there being no overall increase in plasma antioxidant activity, the lipid soluble component of blood antioxidant activity appears to be increased by propofol.”

“This study shows that anesthesia maintained with either propofol or isoflurane increase both hydrophilic and total antioxidant capacity in plasma, but only propofol anesthesia increases plasma &ggr;-tocopherol concentration.”

“Moreover, propofol increased the antioxidant defense of glutathione.”

“We found that propofol decreased hypoxia-induced proinflammatory cytokines (TNFα, IL-1β, and IL-6) in BV2 microglia, significantly suppressed the excessive production of reactive oxygen species, and increased the total antioxidant capacity and superoxide dismutase activity.”

“Significance: Testing the intracellular oxidation levels suggests that this partial protection exerted by propofol , thymol and chlorothymol may be mediated in some way by their antioxidant activities.”

“ Propofol has been reported to inhibit lipid peroxidation in various experimental models (1), to protect cells against oxidative stress, and to increase the antioxidant capacity of plasma in humans (2).”

“The up-regulation of anti-oxidant enzymes such as HO-1, manganese superoxide dismutase (MnSOD) and catalase is also associated with the protective effect of propofol on hypoxia/reoxygenation-induced cell death.”

“These findings suggested that propofol could improve anti-oxidant activity and inhibit synthesis of inflammatory factors to exert a protective effect on cerebral ischemia/reperfusion injury.”